b8kke yi374 322zd k5af4 4dy5t fky3s d5rrd zank7 eay52 2er2n frs4h a9yz2 b3rtd yde9r adsy8 dhdy7 s4i9t t9tdy efiz3 nf5ye fzi2e Praise Todd Howard |

Praise Todd Howard

2021.12.01 15:49 SixteenTimesTheTodd Praise Todd Howard

Praise The Legendary Game Developer Todd Howard
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2021.12.01 15:49 JBaldera27 RG3 Says He Experienced Sexual Harassment in Washington

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2021.12.01 15:49 SBASUX_AZ Approved! Finally. Hang in there guys

Loan increase from 500k to 1,6xx,xxx

Timeline:
- 9/22 received email saying we could apply for increase, submitted all required docs samer day
- 10/12 we get an email from a "Loan specialist" via email asking for a form 413 and a revised SBA form 3501, sent same day
-10/12 later this day, portal got updated to a lower calculated amount, clicked review and accept to accept
-10/13 portal shows " Your loan modification is being processed "
-10/13 called SBA CSR and was told verbally that our loan was approved and we should look out for loan docs in the coming days
- calling every other day getting the same responses
- 11/1 called and was told that there is a system glitch and that they have escalated it and notified the IT team to fix it
- 11/1 Called local AZ SBA office and spoke to a nice gentleman that basically said his hands are tied as he has no access to that "side" of the SBA
- 11/4 I receive a response from that email by a CSR "office of disaster assistance, Field operations center - WEST" and am told "Review of the file shows that your file has been sent to our processing and disbursement support team for further assistance.
- 11/6 get a phone call on a Saturday from a CSR telling me that I need to start a new app as the old one was stuck in a glitch, they send me a link to do so
- 11/6 new app is started
- 11/8 new app is changed to a decline as it says there are duplicate applications, called CSR, they reverted my old "glitched" app to the amount pre increase
- 11/9 new app re-opens and allows me to upload all docs again
- 11/23 get approval email
- 11/24 sign loan docs, CAWeb changes to 1,1xx,xxx "undisbursed - current"
- Checking CAweb daily
- 12/1 (today) CAWeb has updated to (Disbursed - Current)
So I should see funds soon!? I know there are lots of you out there who applied before me and are still waiting, so I feel bad, but I do believe that everyone that has been approved and is waiting for funding will get it eventually, so hang in there.
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2021.12.01 15:49 Nor_Cal_Native Country style holiday season! Barn Chandelier

Country style holiday season! Barn Chandelier submitted by Nor_Cal_Native to mildlyinteresting [link] [comments]


2021.12.01 15:49 Infinite_Ad_6137 (beginner)want to develop something for linux

So ,I have been using linux for while , and wanna make something for linux ,like script or program which can help community to support , and I have been brainstorming how can I use my beginner knowledge of stuff like c/c++/c#/bash , means I want to create something out of this language for linux ,and had no Idea where to start what to do and stuff can anybody help me for any suggestions ,like what can. Be done ,just lit spark , help plz ,
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2021.12.01 15:49 RainbowKitchen Coffee Walnut Double Chocolate Cake

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2021.12.01 15:49 SixteenTimesTheTodd Praise Todd Howard

Praise The Legendary Game Developer Todd Howard
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2021.12.01 15:49 Dildo-Dilettante Gold AG is the embodiment of Cognitive Dissonance. Change my mind.

Gold AG is the embodiment of Cognitive Dissonance. Change my mind. submitted by Dildo-Dilettante to kosovo [link] [comments]


2021.12.01 15:49 mutednavy Please stop

Please whatever I did to upset you guys I’m sorry and whatever you want me to do stop I’ll do it. I’m sorry. I will change. I can’t deal with this anymore. Please stop.
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2021.12.01 15:49 dem0n0cracy Metabolic therapy and bioenergetic analysis: The missing piece of the puzzle

Metabolic therapy and bioenergetic analysis: The missing piece of the puzzle
Full Review Text w/ images : https://www.sciencedirect.com/science/article/pii/S2212877821002404
Highlights • Normal and cancer cells differ in substrate level phosphorylation and mitochondrial rewiring of ATP-generating pathways.
• Glucose and glutamine are two major fuels for tumor growth. Their allocation is dependent on mitochondrial function.
• Secondary metabolites assist in proliferation but cannot fully cover ATP demands.
• Metabolic therapy is a promising cancer management strategy, but standardization and patient stratification is required.
• Bioenergetics can be assessed in vitro using bench top and integrated solutions and in vivo via metabolic imaging.
Abstract Background
Aberrant metabolism is recognized as a hallmark of cancer, a pillar necessary for cellular proliferation. Regarding bioenergetics (ATP generation), most cancers display a preference not only toward aerobic glycolysis (“Warburg effect”) and glutaminolysis (mitochondrial substrate level-phosphorylation) but also toward other metabolites such as lactate, pyruvate, and fat-derived sources. These secondary metabolites can assist in proliferation but cannot fully cover ATP demands.
Scope of review
The concept of a static metabolic profile is challenged by instances of heterogeneity and flexibility to meet fuel/anaplerotic demands. Although metabolic therapies are a promising tool to improve therapeutic outcomes, either via pharmacological targets or press-pulse interventions, metabolic plasticity is rarely considered. Lack of bioenergetic analysis in vitro and patient-derived models is hindering translational potential. Here, we review the bioenergetics of cancer and propose a simple analysis of major metabolic pathways, encompassing both affordable and advanced techniques. A comprehensive compendium of Seahorse XF bioenergetic measurements is presented for the first time.
Major conclusions
Standardization of principal readouts might help researchers to collect a complete metabolic picture of cancer using the most appropriate methods depending on the sample of interest.
https://ars.els-cdn.com/content/image/1-s2.0-S2212877821002404-gr1.jpg
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2021.12.01 15:49 ovarymotionall Pleasurably suffering

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2021.12.01 15:49 lurky79 It wouldn’t be Christmas season without seeing chia pets.

It wouldn’t be Christmas season without seeing chia pets. submitted by lurky79 to funny [link] [comments]


2021.12.01 15:49 costacm Zekrom raid right now

Add 6748 4318 9332
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2021.12.01 15:49 vkevlar I should not have gone back to watch S1.

So... episode 1, attack on NYC. The nanotech is eating the trees, people, everything organic. The Union troops are targetting civilians explicitly and directly. How does this jibe in any way with what we're being told/shown about the Union in S2? Did nano-Heaven need trees?
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2021.12.01 15:49 Bonus1Fact Alec Baldwin exclusive: 'The trigger wasn't pulled. I didn't pull the trigger.' | ABC News ¦ ABC News

Alec Baldwin exclusive: 'The trigger wasn't pulled. I didn't pull the trigger.' | ABC News ¦ ABC News submitted by Bonus1Fact to NewsShorts [link] [comments]


2021.12.01 15:49 johnytestt Orslok no estaba loco después de todo

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2021.12.01 15:49 StPaddy81 It's my 11th CakeDay!

It's my 11th CakeDay! submitted by StPaddy81 to cakeday [link] [comments]


2021.12.01 15:49 Otherwise-Addendum28 Could/Should I retake a class I already completed?

Hey all,
I'm a freshman in college working towards a Computer Science degree. The only problem with that is my CSC-110 is an absolute pain with the amount of work, lack of comprehensive notes and the professor has an extremely thick accent that I cant understand most of the time, this actually lead to like 7 people dropping the course lmao. Now here comes the question, as of now I would pass but barely, feeling like I've learned nothing and I would be absolutely not ready for the next course. So I'm asking if it's possible/smart to retake a course I've already passed? Like, would it look bad on my transcript or anything? Of course, if I end up failing the final really badly and failing the class my decision is already made for me lmao. Sorry if this was confusing to read, I'm on very minimal sleep with a pounding headache and my meds are wearing off lol.
Thanks in advance!
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2021.12.01 15:49 lalo1327 Latam moment

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2021.12.01 15:49 SixteenTimesTheTodd Praise Todd Howard

Praise The Legendary Game Developer Todd Howard
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2021.12.01 15:49 Donhergo Is Curtis Samuel startable in week 13?

I actually didn't see him on the field ever, but his fantasy points in 2020 look nice. However he was injured for like forever and this will be his second (?) game in 2021 - do you think he is worth the try?
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2021.12.01 15:49 Undertale_Woshua These Posts Are All That I See Lol

These Posts Are All That I See Lol submitted by Undertale_Woshua to Undertale [link] [comments]


2021.12.01 15:49 Inevitable_Company_5 not the best place 💀

not the best place 💀 submitted by Inevitable_Company_5 to Darkhumorandjokes [link] [comments]


2021.12.01 15:49 ple49 Help with mech bosses summoner death mode

I saw a progression guide by GitGud, but I still cant seem to get even close to defeating the mech bosses. Any recommendations on gear pre-mechbosses?
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2021.12.01 15:49 Ape_Sauce This Spotify Wrapped 2021 is out!

My most listened to song this year was Polyrhythm and #1 artist was Perfume, what is your Spotify Wrapped looking like this year?
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